Run4Love was developed to reduce high rates of depression among people living with HIV. The intervention consists with a 12-week cognitive behavioral stress management (CBSM) course delivered via enhanced WeChat platform and personalized physical activity promotion program with tracking and personalized feedback on WeChat. The Run4Love has been evaluated with a randomized controlled trial in 300 people living with and depression with 3-, 6-, and 9-month follow-ups. The intervention has led to significant reduction in depression (measured by CES-D), chronic stress, and suicidal behaviors at all follow-ups.
Guo Y, Hong YA, Cai W, Li L, Hao Y, Qiao J, Xu Z, Zhang H, Zeng C, Liu C, Li Y, Zhu M, Zeng Y, Penedo FJ. Effect of a WeChat-Based Intervention (Run4Love) on Depressive Symptoms Among People Living With HIV in China: Randomized Controlled Trial. J Med Internet Res 2020;22(2):e16715. doi: 10.2196/16715
Li Y, Guo Y, Hong YA, Zeng Y, Monroe-Wise A, Zeng C, Zhu M, Zhang H, Qiao J, Xu Z, Cai W, Li L, Liu C. Dose–Response Effects of Patient Engagement on Health Outcomes in an mHealth Intervention: Secondary Analysis of a Randomized Controlled Trial. JMIR Mhealth Uhealth 2022;10(1):e25586 doi: 10.2196/25586
Guo Y, Li Y, Yu C, Xu H, Hong YA, Wang X, Zhang N, Zeng Y, Monroe-Wise A, Li L, Liu C, Cai W, Lin A. Long-term Effects of a Social Media–Based Intervention (Run4Love) on Depressive Symptoms of People Living With HIV: 3-Year Follow-up of a Randomized Controlled Trial. J Med Internet Res 2022;24(6):e36809. doi: 10.2196/36809